亚洲中文字幕无线乱码

科学研究
20190911 SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA
发布时间:2019-09-12  来源:  阅读次数:


Guo, W., Wei, J., Zhong, X., Zang, R., Lian, H., Hu, M.M., Li, S., Shu, H.B.*, and Yang, Q.*(2019). SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA. Cellular & molecular immunology.


Abstract

The mitochondrial virus-induced signaling adaptor (VISA, also called mitochondrial antiviral signaling, MAVS) protein is a central adaptor in the innate immune response to cytosolic viral RNA. Viral infection causes the aggregation of VISA, which is important for its recruitment of downstream signaling components. How VISA aggregation is regulated remains unknown. Here, we found that sorting nexin 8 (SNX8) is a positive regulator of the RNA virus-triggered induction of downstream effector genes and innate immune response. The brains and lungs of Snx8-/- mice infected with RNA viruses exhibited lower serum cytokine levels and higher viral titers than those of wild-type mice, resulting in higher lethality. Mechanistically, viral infection induced the translocation of SNX8 from the cytosol to mitochondria and its increased association with VISA, leading to VISA aggregation, its recruitment of downstream signaling components and the induction of downstream antiviral genes. Our findings suggest that SNX8 is a critical component of the RIG-I-like receptor (RLR)-mediated innate immune response by modulating VISA aggregation and activation.

原文链接:https://www.nature.com/articles/s41423-019-0285-2

地 址:湖北省武汉市武昌区东湖路115号 邮政编码:430071 电 话:027-68750205  邮 箱:mri@whu.edu.cn

CopyRight ? 2016  版权所有:亚洲v视频 日韩a无v码

亚洲中文字幕无线乱码-亚洲v视频 日韩a无v码-家庭乱码伦区中文字幕在线